Semax

Semax 5 mg is a regulatory peptide used for cognitive enhancement and neuroprotection. It is formulated as nasal drops. It works by increasing BDNF (Brain-derived Neurotrophic factor) expression, modulating dopamine/serotonin, and reducing oxidative stress. Semax is used in stroke recovery, ADHD (Attention deficit hyperactivity disorder), memory issues, and anxiety.

Key Features

About
Drug Class	Peptide drug, Nootropics
Subclass	Synthetic ACTH 4-10 fragment analog
Active ingredient	Methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline (Semax) 1%

Semax 5 mg
Composition	Active ingredients Methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline (Semax) 1% Inactive ingredients: Nipagin as preservative Purified water
Packaging Type	Sterile glass vial with dropper cap
Pack Size	5 mg
Dosage	2-3 drops per nostrils
Active ingredients	Methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline (Semax) 1%
Manufacturer	Zycare peptide science
Shelf Life	Two years refrigerated for unopened pens.
Usages	Stroke, TBI, Cognitive disorders, asthenia, optic nerve atrophy, ADHD and Fatigue
Country of Origin	India

How does Semax 5 mg work?

• It may boost BDNF (Brain-derived Neurotrophic factor) and NGF (Nerve growth Factor), as it may raises brain growth factors that improves neuroplasticity, memory, and neuron repair.
• It may modulate dopamine and serotonin as it increases focus, motivation, and mood by upregulating key neurotransmitter systems without stimulant crash.
• It acts on melanocortin receptors as it reduces anxiety and stress by modulating the HPA axis, as well as it has anti-inflammatory effects in brain.
• It may lower oxidative stress and may protects neurons, that is the main reason it is used in stroke recovery.

Usage

• It is used in cognitive enhancement and in fatigue.
• It can be used in dealing with ADHD (Attention deficit hyperactivity disorder) and anxiety.
• It is used as a nootropic.

Dosage

• It can be used as 2-3 drops per nostrils.
• It can be taken in the morning and in early afternoon, but avoid it in late evening due to alertness.

How to use Semax 5 mg?

• Blow your nose gently then wash your hands.
• Instil 2-3 drops per nostrils.
• Squeeze dropper, let drops fall into nostrils. Breath gently and don’t sniff hard or it goes to throat.
• Stay tilted for 30-60 seconds and don’t blow your nose for 15 minutes.
• Repeat for the other nostril.

Side effects

• Dryness
• Burning sensation
• Mild nasal irritation
• Headache
• Mild anxiety
• Insomnia
• High blood pressure
• Skin rash

Interactions

• The stimulants like caffeine, amphetamines, modafinil may increase the risk of overstimulation and anxiety.
• Anxiolytics and sedatives may reduce the effects of benzodiazepines due to opposing HPA axis action.
• MAOIs may increase the risk of serotonin syndrome.

Pharmacokinetics

• Semax 5 mg onset of action 5-15 minutes, and it may reach peak at just 20-60 minutes.
• The half-life is approx. 20 minutes in blood, but CNS effects last 4-6 hours due to gene expression changes.
• Metabolites get cleared renally.

Precautions

• Pregnant and breast-feeding women should avoid using any such medications.
• The one with prior medical condition like psychotic history, anxiety, hypertension, bipolar disorder should avoid taking any such medications.
• In the condition of cardiac issues or high blood pressure it may can cause anxiety.

Conclusion

Semax 5 mg is a synthetic ACTH (Adrenocorticotropic hormone) 4-10 analog with neuroprotective and cognitive-enhancer, it may work via BDNF (Brain-derived Neurotrophic factor) upregulation, dopamine and serotonin modulation and anti-inflammatory action, not through metabolic hormones like GLP-1 it is used in improving focus, memory, stress, resilience and stroke recovery. It may show some side effects like dryness, burning sensation, mild nasal irritation, headache, mild anxiety, insomnia, high blood pressure and skin rash. This side effects may can vary from individual to individual, it is advised to consult healthcare provider prior using any such medications.

FAQs

• What for Semax 5 mg is used?
  Semax is a neuroprotective and cognitive enhancer that is used in stroke recovery, ADHD (Attention deficit hyperactivity disorder), memory issues, and anxiety.

• How does Semax 5 mg work?
  Semax 5 mg may work by increasing BDNF (Brain-derived Neurotrophic factor) expression, modulating dopamine/serotonin, and reducing oxidative stress.

• What can be the possible side effects of Semax 5 mg?
  The possible side effects of Semax 5 mg can be dryness, burning sensation, mild nasal irritation, headache, mild anxiety, insomnia, high blood pressure and skin rash.

• Who should avoid using Semax 5 mg?
  Pregnant and breast-feeding women and the one with prior medical history like psychotic history, cardiac issues, high blood pressure anxiety, hypertension, bipolar disorder should avoid using Semax 5 mg.

• How fast does Semax 5 mg works?
  It may reach the peak plasma concentration in just 1-2 hours.